1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE
DIFENZOQUAT METHYLSULFATE
CAS: 43222-48-6
Molecular Formula: C18H20N2O4S
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Names and Identifiers
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Physico-chemical Properties
| Molecular Formula | C18H20N2O4S |
| Molar Mass | 360.43 |
| Melting Point | 146-148℃ (acetone ) |
| Storage Condition | 2-8℃ |
| MDL | MFCD00055342 |
| Physical and Chemical Properties | The pure chemical product is a white solid with hygroscopicity. M. p.155 ~ 157 ℃, vapor pressure 1.33 × 10-5Pa (20 ℃), relative density 1.13. Solubility in water is 76%(25 ℃), 78%(37 ℃) and 85%(56 ℃); Slightly soluble in methanol and ethanol; Insoluble in petroleum hydrocarbons. The aqueous solution (pH 3~3.4) is stable to light and acidic conditions, unstable to alkali, and has no effect on storage at 120 ℃ for 169h. Industrial product content> 96%,m.p.150~160 ℃. |
| Use | Use of selective post-shoot stem and leaf treatment agent. It is mainly used to control wild oats. After the medicine is applied to the leaves of wild oats, it is absorbed and transferred to the heart of the leaves, acting on the growing point, destroying the cell division of Wild Oats and the division and elongation of cells in the apical and internodal meristem of wild oats, so as to stop its growth, and finally the whole plant died. For the control of barley, wheat and rye field Wild Oats, with 64% soluble powder 11.3~22.5g/100 m2, the water 7.5kg spray. Generally used in the bud after 3~5 leaf stage. |
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | 2588 |
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Upstream Downstream Industry
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Nature
| storage conditions | 0-6°C |
| morphology | neat |
| Merck | 13,3163 |
| BRN | 4093655 |
| EPA chemical information | Difenzoquat methyl sulfate (43222-48-6) |
Last Update：2024-04-10 22:29:15
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Uses and synthesis methods
Toxicity
the original drug has an acute oral LD50239 of ~ 470 mg/kg in rats and 31 mg/kg in mice. The acute percutaneous LD50 of male rabbits is 3540 mg/kg. Slight irritation to the skin and eyes. There was no abnormality in the three-generation reproduction test and delayed neurotoxicity test. The non-effective dose of rats was 500 mg/kg in the 2-year feeding test, and the non-effective dose of dogs was 2.5 g/kg per day for 3 months. No carcinogenic, teratogenic and mutagenic effects were found in animal experiments. Carp LC50>100mg/L (96h); The acute oral LD50 of wild ducks is> 1000mg/kg, and the LD50 of bees is 36.2 μg/duck.
use
pyrazole is an efficient, highly selective and low toxicity herbicide, which is mainly used to control wild oats in wheat and barley fields.
production method
Synthesized according to the following steps:(1) Synthesis of 2, 3-epoxy -1, 3-diphenylaceton-1 (called epoxide) from acetophenone, benzaldehyde and hydrogen peroxide. (2) Synthesis of 3, 5-diphenylpyrazole from 2, 3-epoxy -1, 3-diphenylaceton-1 and hydrazine hydrate. (3)3, 5-diphenylpyrazole reacts with dimethyl sulfate to obtain pyrazole. Raw material consumption quota: acetophenone (industrial product) 660 kg/t, benzaldehyde (95%)590 kg/t, sodium hydroxide (95%)190 kg/t, ethanol (95%)140 kg/t, hydrazine hydrate (85%)290 kg/t, xylene 270 kg/t, hydrogen peroxide (30%)770 kg/t, p-toluene sulfonic acid (industrial product) 20 kg/t, dimethyl sulfate (95%).
preparation of 3,5-diphenylpyrazole benzene and acetyl chloride are prepared by acetophenone under the catalysis of anhydrous aluminum trichloride. acetophenone and benzaldehyde are prepared by reacting ethanol as solvent at room temperature for 4h under the storage of catalytic amount of sodium hydroxide. hydrazine hydrate is added at a temperature not exceeding 30 ℃, stirring is completed for 15min, most of the ethanol is heated and evaporated, 5-Diphenylpyrazoline is put into the dehydrogenation reactor while it is hot. Using xylene as solvent, sulfur is added in batches at the temperature, and the attached xylene is steamed out. The reaction temperature continues to rise to 160 ℃ for 1~1.5h. After a little cooling, the distilled xylene is slowly added, cooled to room temperature, and filtered to obtain 3, 5-diphenylpyrazole.
the synthesis of 3, 5-diphenylpyrazole and chlorobenzene (which can also be still in xylene solution), sodium hydroxide and PTC are heated and refluxed. after a certain period of reaction, dimethyl sulfate is added dropwise. after 1~2h of reaction, the temperature is cooled and washed with water to remove sodium sulfate to obtain 1-methyl -3, 5-diphenylpyrazole. Add slightly excess dimethyl sulfate and react below 100 ℃ for 2~3h. The oats produced by water extraction are withered, and the chlorobenzene layer is also extracted with water, and the water phase is combined to obtain the wild swallow dry water solution.
category
Pesticides
toxicity classification
High toxicity
acute toxicity
oral-rat LD50: 270 mg/kg
flammability hazard characteristics
Flammable; combustion produces toxic nitrogen oxides and sulfur oxide smoke
storage and transportation features
Ventilated and dry at low temperature; stored separately from warehouse food ingredients
fire extinguishing agent
Dry powder, foam, sand, carbon dioxide, mist water
Last Update：2024-04-10 22:29:15
1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE - Security information
| WGK Germany | 3 |
| RTECS number | UQ9820000 |
| HazardClass | 6.1( B ) |
| PackingGroup | III |
| Toxicity | LD50 (technical grade) orally in rats: 470 mg/kg; dermally in rabbits: 3540 mg/kg (Shafer) |
Last Update：2024-04-10 22:29:15
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Product Name: Difenzoquat methyl sulfate Visit Supplier Webpage Request for quotation
CAS: 43222-48-6
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CAS: 43222-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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View History
Raw Materials for 1,2-DIMETHYL-3,5-DIPHENYL-1H-PYRAZOLIUM METHYL SULFATE
Hydrogen peroxide
Xylene
Hydrazine, hydrate (1:1)
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Expoxide
1,3-Diphenylacetone
Difenzoquat
Xylene
Hydrazine, hydrate (1:1)
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Expoxide
1,3-Diphenylacetone
Difenzoquat